A keyboard frame with induction light source is disclosed, which comprises: a frame, a light guide plate, a signal line, a thermal sensor, a light source, a control circuit and a switch. As the light guide plate having the signal line disposed thereon is received in the frame while the thermal sensor and the light source is further disposed on the signal line and connected thereto, temperatures of a hand detected by the thermal sensor is transmitted to the control circuit where it is converted into electric signals and then send to the light source for directing the same to perform a color changing operation accordingly and thus cause the keyboard frame to display various coloring/lighting effects. With the aforesaid structure, not only the keyboard frame is fun to play for its ability to display various lighting/coloring effects, but also it is able to act as a thermometer for measuring human body's temperature. Moreover, the switch is used for controlling the on/off of the light source so that the keyboard frame can be personalized based on users preferences.