Invention Grant
- Patent Title: Compositions and methods for therapy and diagnosis of cancer
- Patent Title (中): 癌症治疗和诊断的组成和方法
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Application No.: US12096216Application Date: 2006-12-07
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Publication No.: US08088913B2Publication Date: 2012-01-03
- Inventor: Ugur Sahin , Özlem Türeci , Michael Koslowski
- Applicant: Ugur Sahin , Özlem Türeci , Michael Koslowski
- Applicant Address: DE Mainz DE Mainz
- Assignee: Ganymed Pharmaceuticals AG,Johannes Gutenberg-Universitat Mainz
- Current Assignee: Ganymed Pharmaceuticals AG,Johannes Gutenberg-Universitat Mainz
- Current Assignee Address: DE Mainz DE Mainz
- Agency: McAndrews, Held & Malloy Ltd.
- Priority: EP05026874 20051208
- International Application: PCT/EP2006/011785 WO 20061207
- International Announcement: WO2007/065690 WO 20070614
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; C12N15/63 ; A61K48/00
Abstract:
The present invention is directed to siRNA molecules which specifically target and cause RNAi-induced degradation of mRNA from TPTE genes, so that the protein product of the TPTE gene is not produced or is produced in reduced amounts. The siRNA compounds and compositions of the invention are useful for treating diseases which require inhibition of TPTE expression for their treatment, in particular cancer pathologies. The present invention also includes methods which make possible to assess and/or prognose the metastatic behavior of a cancer disease and/or the occurrence of a relapse of cancer.
Public/Granted literature
- US20090221674A1 COMPOSITIONS AND METHODS FOR THERAPY AND DIAGNOSIS OF CANCER Public/Granted day:2009-09-03
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