Invention Grant
US08088909B2 Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in the method
有权
离体动物或挑战模型作为测量针对寄生虫和疫苗的保护性免疫的方法，显示在该方法中是保护性的
- Patent Title: Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in the method
- Patent Title (中): 离体动物或挑战模型作为测量针对寄生虫和疫苗的保护性免疫的方法，显示在该方法中是保护性的
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Application No.: US12800205Application Date: 2010-05-10
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Publication No.: US08088909B2Publication Date: 2012-01-03
- Inventor: Florine Johanna van Milligen , Johannes Bernardus Wilhelmus Joseph Cornelissen , Bernard Adri Bokhout
- Applicant: Florine Johanna van Milligen , Johannes Bernardus Wilhelmus Joseph Cornelissen , Bernard Adri Bokhout
- Applicant Address: NL Wageningen
- Assignee: Stichting Dienst Landbouwkundig Onderzoek
- Current Assignee: Stichting Dienst Landbouwkundig Onderzoek
- Current Assignee Address: NL Wageningen
- Agency: TraskBritt
- Priority: EP97200730 19970311
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K39/00 ; C12N15/00
Abstract:
The invention relates to an ex vivo animal or challenge model as a method to identify protective (recombinant) proteins and rapidly measure protective immunity in intestinal segments directed against parasites and vaccines directed against parasitic infections. The invention further relates to vaccines directed against infection with parasites, such as Fasciola hepatica, which vaccines contain protective (recombinant) proteins identified and shown to be protective in studies using the ex vivo model. The invention further relates to protective (recombinant) proteins obtained from newly excysted juveniles (NEJ) of Fasciola hepatica. The protective (recombinant) protein corresponding to an NEJ protein has an apparent molecular weight of 32 kD and an N-terminal amino acid sequence comprising the sequence XXDVSWPFWDRMYNY (SEQ ID NO:1).
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