Invention Grant
- Patent Title: Peptides and peptidomimetic compounds, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition
- Patent Title (中): 肽和拟肽化合物,其制备及其用于制备治疗和/或预防性活性药物组合物的用途
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Application No.: US12239579Application Date: 2008-09-26
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Publication No.: US08088890B2Publication Date: 2012-01-03
- Inventor: Peter Petzelbauer , Sonja Reingruber , Rainer Henning
- Applicant: Peter Petzelbauer , Sonja Reingruber , Rainer Henning
- Applicant Address: AT Vienna
- Assignee: Fibrex Medical Research & Development GmbH
- Current Assignee: Fibrex Medical Research & Development GmbH
- Current Assignee Address: AT Vienna
- Agency: Maschoff Gilmore & Israelsen
- Main IPC: A61K38/04
- IPC: A61K38/04 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00

Abstract:
Peptides, peptidomimetics and derivatives thereof of the general formula I: H2N-GHRPX1-β-X4X5X6X7X8X9X10-X11 (I), in which X1-X10 denote one of the 20 genetically coded amino acids, wherein X8, X9 and X10 may also denote a single chemical bond; X11 denotes OR1 in which R1 equals hydrogen or (C1-C10) alkyl NR2R3 with R2 and R3 are equal or different and denote hydrogen, (C1-C10) alkyl, or a residue —W-PEG5-60K, in which the PEG residue is attached via a suitable spacer W to the N-atom, or a residue NH—Y—Z-PEG5-60K, in which Y denotes a chemical bond or a genetically coded amino acids from the group S, C, K or R and Z denotes a spacer, via which a polyethylene glycol (PEG)-residue can be attached, and their physiologically acceptable salts, and β denotes an amino acid, or a peptidomimetic element, which induces a bend or turn in the peptide backbone.
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