Invention Grant
US08088817B2 Pyrrole derivative having, as substituents, ureido group, aminocarbonly group and bicyclic group which may have substituent
失效
作为取代基的吡咯衍生物，可以具有取代基的脲基，氨基碳基和双环
- Patent Title: Pyrrole derivative having, as substituents, ureido group, aminocarbonly group and bicyclic group which may have substituent
- Patent Title (中): 作为取代基的吡咯衍生物，可以具有取代基的脲基，氨基碳基和双环
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Application No.: US12737807Application Date: 2009-08-25
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Publication No.: US08088817B2Publication Date: 2012-01-03
- Inventor: Kenji Kawashima , Noriko Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
- Applicant: Kenji Kawashima , Noriko Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
- Applicant Address: JP Osaka-Shi, Osaka
- Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Osaka-Shi, Osaka
- Agency: Holtz, Holtz, Goodman & Chick, PC
- Priority: JP2008-214773 20080825
- International Application: PCT/JP2009/064744 WO 20090825
- International Announcement: WO2010/024227 WO 20100304
- Main IPC: A61K31/4025
- IPC: A61K31/4025 ; A61K31/401 ; C07D207/34 ; C07D405/04 ; C07D409/04
Abstract:
A compound represented by the following formula (1) or a salt thereof: The compound has an inhibitory activity on the production of interleukin-6, and is therefore useful as a therapeutic agent for a disease associated with interleukin-6, ocular inflammatory diseases and the like. In the formula, R1 represents a halogen atom, a hydrogen atom, a lower alkyl group which may have a substituent, a formyl group, or a lower alkylcarbonyl group which may have a substituent, R2 represents a bicyclic hydrocarbon group which may have a substituent or a bicyclic heterocyclic group which may have a substituent, R3 represents a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, or an acyl group.
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