Invention Grant
US08088802B2 N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation
失效
N-苯基芳基磺酰胺化合物,包含该化合物作为活性成分的药物组合物,该化合物的合成中间体及其制备方法
- Patent Title: N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation
- Patent Title (中): N-苯基芳基磺酰胺化合物,包含该化合物作为活性成分的药物组合物,该化合物的合成中间体及其制备方法
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Application No.: US12603194Application Date: 2009-10-21
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Publication No.: US08088802B2Publication Date: 2012-01-03
- Inventor: Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
- Applicant: Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
- Applicant Address: JP Osaka
- Assignee: Ono Pharmaceutical Co., Ltd.
- Current Assignee: Ono Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Sughrue Mion, PLLC
- Priority: JP2001-068498 20010312; JP2001-281569 20010917; JP2002-007760 20020116
- Main IPC: A61K31/41
- IPC: A61K31/41 ; C07D421/00 ; C07D417/00 ; C07D413/00 ; C07D285/08 ; C07D271/06 ; C07D257/04 ; C07D307/00

Abstract:
An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
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