Invention Grant
US08088747B2 Analogue compounds of archaebacterial membrane lipids and liposomal compounds integrating such compounds
有权
古细菌膜脂质的模拟化合物和整合这些化合物的脂质体化合物
- Patent Title: Analogue compounds of archaebacterial membrane lipids and liposomal compounds integrating such compounds
- Patent Title (中): 古细菌膜脂质的模拟化合物和整合这些化合物的脂质体化合物
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Application No.: US11792011Application Date: 2005-12-07
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Publication No.: US08088747B2Publication Date: 2012-01-03
- Inventor: Thierry Benvegnu , Daniel Plusquellec , Gildas Rethore , Mickaelle Scahet , Claude Ferec , Tristan Montier , Pascal Delepine , Pierre Lehn
- Applicant: Thierry Benvegnu , Daniel Plusquellec , Gildas Rethore , Mickaelle Scahet , Claude Ferec , Tristan Montier , Pascal Delepine , Pierre Lehn
- Applicant Address: FR Cedex FR Cedex
- Assignee: Ecole Nationale Superieure de Chime de Rennes,Universite de Bretagne Occidentale
- Current Assignee: Ecole Nationale Superieure de Chime de Rennes,Universite de Bretagne Occidentale
- Current Assignee Address: FR Cedex FR Cedex
- Agency: Thomas, Kayden, Horstemeyer & Risley, LLP
- Priority: FR0413028 20041207
- International Application: PCT/EP2005/056555 WO 20051207
- International Announcement: WO2006/061396 WO 20060615
- Main IPC: A61K31/7105
- IPC: A61K31/7105 ; A61K31/711 ; A61K9/127 ; C07C35/06 ; C07C43/115
Abstract:
The invention relates to a compound of general formula (I): where X=0 or 1, Z=O, S or CH2, R1 and R2 independently=OH or OY, where Y=a protecting group, OR3, where R3=a monosaccharide or disaccharide group, A1-CH2—N+(CH3)3, X′, where X=halogen, A1=an amide (NHC(O)) or ester (OC(C)) bond, OPO(OM)2, where M=an alkyli or alkyli earth metal, OP(O)O−—O(CH2)2—N+(CH3)3, A2-(PEGX1-A3)n-R4, where n=0 or 1, PEGX1=a polyethyleneglycol of molecular weight X1, where X1 being less than or equal to 5,000 daltons, A2 and A3 independently=a ether (O), ester (OC(O)), amide (NHC(O)), urea (NHC(O)NH), thiourea (NHC(S)NH), or thioether (S) bond R4=a directing agent.
Public/Granted literature
- US20090232880A1 Analogue Compounds Of Archaebacterial Membrane Lipids And Liposomal Compounds Integrating Such Compounds Public/Granted day:2009-09-17
Information query
IPC分类:
