Invention Grant
US08088599B2 Nucleic acids encoding genetically modified tissue factor pathway inhibitor (TFPI) and method of making the same
失效
编码遗传修饰的组织因子途径抑制剂（TFPI）的核酸及其制备方法
- Patent Title: Nucleic acids encoding genetically modified tissue factor pathway inhibitor (TFPI) and method of making the same
- Patent Title (中): 编码遗传修饰的组织因子途径抑制剂（TFPI）的核酸及其制备方法
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Application No.: US12407529Application Date: 2009-03-19
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Publication No.: US08088599B2Publication Date: 2012-01-03
- Inventor: Duan Ma , Jingui Mu , Jiping Wang , Huijun Wang , Wang Liang
- Applicant: Duan Ma , Jingui Mu , Jiping Wang , Huijun Wang , Wang Liang
- Applicant Address: CN Shanghai
- Assignee: Fudan University
- Current Assignee: Fudan University
- Current Assignee Address: CN Shanghai
- Agent Yuan Qing Jiang
- Priority: CN200910016024 20090206
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12N1/00 ; C12N15/00 ; C12N15/74
Abstract:
The present invention provides long half life genetically modified TFPI sequences (LTFPI) for anticoagulation. On the genetically modified TFPI sequence, the lysine at the carboxy-terminal sites 241, 254, 260 and 261 are replaced by alanin and the amino acid asparagine at glycosylation sites 117, 167, 228 and the amino acids serine and threonine at glycosylation sites 174 and 175 are substitutionally mutated. The present invention also provides methods of making the LTFPI through high efficient LTFPI expression from yeast production system.
Public/Granted literature
- US20100204095A1 Genetically Modified TFPI And Method Of Making The Same Public/Granted day:2010-08-12
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