Invention Grant
- Patent Title: Blood pressure lowering peptides from glycomacropeptide
- Patent Title (中): 来自糖巨肽的血压降低肽
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Application No.: US11884448Application Date: 2006-02-23
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Publication No.: US08088597B2Publication Date: 2012-01-03
- Inventor: Andre Leonardus De Roos , Pieter Marinus Van Den Broecke , Luppo Edens
- Applicant: Andre Leonardus De Roos , Pieter Marinus Van Den Broecke , Luppo Edens
- Applicant Address: NL Heerlen
- Assignee: DSM IP Assets B.V.
- Current Assignee: DSM IP Assets B.V.
- Current Assignee Address: NL Heerlen
- Agency: Nixon & Vanderhye P.C.
- Priority: EP05101417 20050224; EP05110236 20051101
- International Application: PCT/EP2006/060198 WO 20060223
- International Announcement: WO2006/089921 WO 20060831
- Main IPC: C12P21/06
- IPC: C12P21/06 ; A61K38/06

Abstract:
A process to produce IPP from a protein source whereby the protein source comprises a protein having the -I-P-P- sequence and having in the protein amino acid sequence at least 6 times more -I-P-P- present than -V-P-P- (molar basis) which comprises hydrolysing the protein source to liberate at least 40% of the I-P-P- sequence into the peptide IPP and whereby a proteolytic enzyme is used which cleaves at the carboxy-terminus of proline residues present in the protein source, the enzyme is preferably a proline specific endoprotease or proline specific oligopeptidase, more preferably a proline specific endoprotease, and optionally an amino peptidase.
Public/Granted literature
- US20080161227A1 Blood Pressure Lowering Peptides From Glycomacropeptide Public/Granted day:2008-07-03
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