Invention Grant
US08088380B2 Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof
有权
结合EGFR的抗原结合分子，编码相同的载体及其用途
- Patent Title: Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof
- Patent Title (中): 结合EGFR的抗原结合分子，编码相同的载体及其用途
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Application No.: US12724386Application Date: 2010-03-15
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Publication No.: US08088380B2Publication Date: 2012-01-03
- Inventor: Pablo Uma{tilde under (n)}a , Ekkehard Mössner
- Applicant: Pablo Uma{tilde under (n)}a , Ekkehard Mössner
- Applicant Address: CH Schlieren-Zurich
- Assignee: Roche GlycArt AG
- Current Assignee: Roche GlycArt AG
- Current Assignee Address: CH Schlieren-Zurich
- Agency: Sterne, Kessler, Goldstein & Fox PLLC
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; C12P21/08 ; C07K16/28
Abstract:
The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human EGFR. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Public/Granted literature
- US20100233080A1 Antigen Binding Molecules that Bind EGFR, Vectors Encoding Same, and Uses Thereof Public/Granted day:2010-09-16
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