Invention Grant
- Patent Title: Hydrate forms of AMG706
- Patent Title (中): 水合物形式的AMG706
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Application No.: US11627803Application Date: 2007-01-26
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Publication No.: US07989631B2Publication Date: 2011-08-02
- Inventor: Gonzalo Alva , Seshadri Neervannan
- Applicant: Gonzalo Alva , Seshadri Neervannan
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Joseph W. Bulock
- Main IPC: C07D401/14
- IPC: C07D401/14
Abstract:
The anti-angiogenic drug AMG 706 is provided in the mono-phosphate hydrate form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at least a detectable amount, as AMG 706 phosphate dihydrate. Also provided are processes for preparing AMG 706 phosphate dihydrate, AMG 706 drug substance of the invention, and a pharmaceutical composition of the invention. Also provided is a method of treating a medical condition or disorder in a subject where treatment with an anti-angiogenic is indicated, comprising administering, for example orally, a composition of the invention in a therapeutically effective amount.
Public/Granted literature
- US20080039501A1 HYDRATE FORMS OF AMG706 Public/Granted day:2008-02-14
Information query
