Invention Grant
US07989629B2 3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl) propanoic or propenoic acid as H1 and H3 receptor antagonists for the treatment of inflammatory and/or allergic disorders
失效
3-（4 - {[4-（4 - {[3-（3,3-二甲基-1-哌啶基）丙基]氧基}苯基）-1-哌啶基]羰基} -1-萘基）丙酸或丙烯酸 H1和H3受体拮抗剂用于治疗炎性和/或过敏性疾病
![3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl) propanoic or propenoic acid as H1 and H3 receptor antagonists for the treatment of inflammatory and/or allergic disorders](/docs/US/2011-08-02/US07989629B2/abs.jpg.600x600.jpg)
- Patent Title: 3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl) propanoic or propenoic acid as H1 and H3 receptor antagonists for the treatment of inflammatory and/or allergic disorders
- Patent Title (中): 3-（4 - {[4-（4 - {[3-（3,3-二甲基-1-哌啶基）丙基]氧基}苯基）-1-哌啶基]羰基} -1-萘基）丙酸或丙烯酸 H1和H3受体拮抗剂用于治疗炎性和/或过敏性疾病
-
Application No.: US12158185Application Date: 2006-12-19
-
Publication No.: US07989629B2Publication Date: 2011-08-02
- Inventor: Simon Teanby Hodgson , Panayiotis Alexandrou Procopiou , Maria Victoria Vinader Brugarolas
- Applicant: Simon Teanby Hodgson , Panayiotis Alexandrou Procopiou , Maria Victoria Vinader Brugarolas
- Applicant Address: GB Greenford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Greenford, Middlesex
- Agent James P. Riek
- Priority: GB0525897.5 20051220; GB0623217.7 20061121
- International Application: PCT/EP2006/069943 WO 20061219
- International Announcement: WO2007/071691 WO 20070628
- Main IPC: C07D211/20
- IPC: C07D211/20 ; A61K31/451
![3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl) propanoic or propenoic acid as H1 and H3 receptor antagonists for the treatment of inflammatory and/or allergic disorders](/abs-image/US/2011/08/02/US07989629B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a compound of formula (I), or a salt thereof wherein the naphthalene ring is substituted in the 2, 3, 4, 5, 6, 7 or 8 position by R1, and R1 represents —CH2CH2COOH or —CH═C(CH3)COOH, and to processes for their preparation, to compositions containing them and to their use in the treatment of various inflammatory and/or allergic diseases, such as diseases such as allergic rhinitis.
Public/Granted literature
Information query
