Method of altering the binding specificity of monoclonal antibodies by oxidation-reduction reactions

Invention Grant

US07989596B2 Method of altering the binding specificity of monoclonal antibodies by oxidation-reduction reactions 有权

Title translation: 通过氧化还原反应改变单克隆抗体的结合特异性的方法

Patent Title: Method of altering the binding specificity of monoclonal antibodies by oxidation-reduction reactions
Patent Title (中): 通过氧化还原反应改变单克隆抗体的结合特异性的方法
Application No.: US11857608

Application Date: 2007-09-19
Publication No.: US07989596B2

Publication Date: 2011-08-02
Inventor: John A. McIntyre
Applicant: John A. McIntyre
Applicant Address: US IN Beech Grove
Assignee: Redox-Reactive Reagents LLC
Current Assignee: Redox-Reactive Reagents LLC
Current Assignee Address: US IN Beech Grove
Agency: Antonelli, Terry, Stout & Kraus, LLP.
Main IPC: C07K16/00
IPC: C07K16/00 ; A61K39/395 ; C07D487/22

Abstract:

The binding specificity of a monoclonal antibody is altered by exposing the monoclonal antibody to an oxidizing agent or an electric potential.

Abstract(Chinese):

通过将单克隆抗体暴露于氧化剂或电位来改变单克隆抗体的结合特异性。

Public/Granted literature

Information query

Espacenet

IPC分类:

C	化学；冶金
C07	有机化学
C07K	肽（含有β-内酰胺的肽入C07D；在分子中除了形成本身的肽环外不含有任何其他的肽键的环状二肽，如哌嗪-2,5-二酮入C07D；环肽型麦角生物碱入C07D519/02；单细胞蛋白质、酶入C12N；获得肽的基因工程方法入C12N15/00）
C07K16/00	免疫球蛋白，例如，单克隆或多克隆抗体