Invention Grant
US07989451B2 Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments
有权
三环1,2,4-三嗪氧化物和治疗用于癌症治疗的组合物
- Patent Title: Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments
- Patent Title (中): 三环1,2,4-三嗪氧化物和治疗用于癌症治疗的组合物
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Application No.: US11887368Application Date: 2006-03-31
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Publication No.: US07989451B2Publication Date: 2011-08-02
- Inventor: Michael Patrick Hay , Adrian Blaser , William Alexander Denny , Kevin Owen Hicks , Ho Huat Lee , Karin Pchalek , Frederik Bastiaan Pruijn , Bronwyn Gae Siim , William Robert Wilson , Shangjin Yang
- Applicant: Michael Patrick Hay , Adrian Blaser , William Alexander Denny , Kevin Owen Hicks , Ho Huat Lee , Karin Pchalek , Frederik Bastiaan Pruijn , Bronwyn Gae Siim , William Robert Wilson , Shangjin Yang
- Applicant Address: NZ Auckland
- Assignee: Auckland Uniservices Limited
- Current Assignee: Auckland Uniservices Limited
- Current Assignee Address: NZ Auckland
- Agency: Nixon & Vanderhye
- Priority: NZ539152 20050331; NZ542556 20050922
- International Application: PCT/NZ2006/000064 WO 20060331
- International Announcement: WO2006/104406 WO 20061005
- Main IPC: A01N43/64
- IPC: A01N43/64 ; A01N43/62 ; A61K31/53 ; A61K31/55 ; C07D253/08 ; C07D487/00
Abstract:
The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula I and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
Public/Granted literature
- US20090186886A1 Tricyclic 1,2,4-Triazine Oxides and Compositions for Therapeutic Use in Cancer Treatments Public/Granted day:2009-07-23
Information query
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