2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity

Invention Grant

US07989431B2 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity 有权

Title translation: 具有A2A激动剂活性的具有修饰的5'-核糖基团的2-丙炔基腺苷类似物

Patent Title: 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity
Patent Title (中): 具有A2A激动剂活性的具有修饰的5'-核糖基团的2-丙炔基腺苷类似物
Application No.: US12487235

Application Date: 2009-06-18
Publication No.: US07989431B2

Publication Date: 2011-08-02
Inventor: Jayson M. Rieger , Joel M. Linden , Timothy L. Macdonald , Gail W. Sullivan , Lauren J. Murphree , Robert Alan Figler
Applicant: Jayson M. Rieger , Joel M. Linden , Timothy L. Macdonald , Gail W. Sullivan , Lauren J. Murphree , Robert Alan Figler
Applicant Address: US VA Charlottesville
Assignee: University of Virginia Patent Foundation
Current Assignee: University of Virginia Patent Foundation
Current Assignee Address: US VA Charlottesville
Agency: Schwegmann, Lundberg & Woessner, P.A.
Main IPC: A01N43/04
IPC: A01N43/04 ; A61K31/70

Abstract:

The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.

Abstract(Chinese):

本发明提供具有以下通式（I）的化合物：其中X，R 1，R 2，R 7和Z如本文所述。

Public/Granted literature

Information query

Espacenet

IPC分类:

A	人类生活必需
A01	农业；林业；畜牧业；狩猎；诱捕；捕鱼
A01N	人体、动植物体或其局部的保存（食品或粮食的保存入A23）；杀生剂，例如作为消毒剂，作为农药或作为除草剂（杀灭或防止不期望生物体的生长或繁殖的医用、牙科用或梳妆用的配制品入A61K）；害虫驱避剂或引诱剂；植物生长调节剂
A01N43/00	含有杂环化合物的杀生剂、害虫驱避剂或引诱剂，或植物生长调节剂（含有环酐，环状亚胺的化合物入A01N37/00；含有分子式Xm……CnNCC的化合物，即仅含1个杂环，其中m≥1和n≥0及NCC是未取代的或是烷基取代的吡咯烷、哌啶、吗啉、硫代吗啉、哌嗪或带有4个或更多CH2基的聚亚甲基亚胺的化合物入A01N33/00至A01N41/12；含环丙烷羧酸或其衍生物，如具有杂环的酯入A01N53/00）
A01N43/02	.具有带1个或更多的氧或硫原子作为仅有的环杂原子的环
A01N43/04	..带有1个杂原子