Invention Grant
US07989193B2 Compositions and methods for producing gamma-carboxylated proteins
有权
用于产生γ-羧化蛋白质的组合物和方法
- Patent Title: Compositions and methods for producing gamma-carboxylated proteins
- Patent Title (中): 用于产生γ-羧化蛋白质的组合物和方法
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Application No.: US11572870Application Date: 2006-04-10
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Publication No.: US07989193B2Publication Date: 2011-08-02
- Inventor: Ann Lövgren
- Applicant: Ann Lövgren
- Applicant Address: GB Cambridge
- Assignee: MedImmune Limited
- Current Assignee: MedImmune Limited
- Current Assignee Address: GB Cambridge
- Agency: Fish & Richardson P.C.
- Priority: SE0500831 20050413
- International Application: PCT/SE2006/000426 WO 20060410
- International Announcement: WO2006/110083 WO 20061019
- Main IPC: C12N1/20
- IPC: C12N1/20 ; C12N15/00 ; C12N9/00 ; C12N9/02 ; C12N9/14 ; C12Q1/00 ; C12Q1/68 ; C12P21/04 ; C07H21/04 ; C07K1/00
Abstract:
The present invention relates a host cell comprising an expression vector comprising a nucleic acid molecule encoding a protein requiring gamma-carboxylation and associated expression control sequences and a nucleic acid molecule encoding a vitamin K epoxido reductase and associated expression control sequences and a nucleic acid molecule encoding a γ-glutamyl carboxylase and associated control sequences. The invention further relates to a method of producing a protein requiring gamma-carboxylation in high yields.
Public/Granted literature
- US20080312127A1 Host Cell Comprising a Vector for Production of Proteins Requiring Gamma-Carboxylation Public/Granted day:2008-12-18
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