Invention Grant
US07989161B2 Methods for determining human immunodeficiency virus type 2 (HIV-2) protease sensitivity or resistance to antivirals utilizing an inducible yeast expression system
有权
使用诱导型酵母表达系统测定人类免疫缺陷病毒2型（HIV-2）蛋白酶敏感性或对抗病毒药物抗性的方法
- Patent Title: Methods for determining human immunodeficiency virus type 2 (HIV-2) protease sensitivity or resistance to antivirals utilizing an inducible yeast expression system
- Patent Title (中): 使用诱导型酵母表达系统测定人类免疫缺陷病毒2型（HIV-2）蛋白酶敏感性或对抗病毒药物抗性的方法
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Application No.: US11628120Application Date: 2005-06-02
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Publication No.: US07989161B2Publication Date: 2011-08-02
- Inventor: Pablo Gluschankof , Didier Raoult , Najoua Ben M'Barek , Gilles Audoly
- Applicant: Pablo Gluschankof , Didier Raoult , Najoua Ben M'Barek , Gilles Audoly
- Applicant Address: FR FR
- Assignee: Université de la Méditérranée,Centre National de la Recherche Scientifique - CNRS
- Current Assignee: Université de la Méditérranée,Centre National de la Recherche Scientifique - CNRS
- Current Assignee Address: FR FR
- Agency: DLA Piper LLP (US)
- Priority: FR0405945 20040602
- International Application: PCT/FR2005/001356 WO 20050602
- International Announcement: WO2006/000693 WO 20060105
- Main IPC: A61K39/21
- IPC: A61K39/21 ; C12Q1/70 ; C12P21/06
Abstract:
A method for determining sensitivity or resistance of isolates of HIV (human immunodeficiency virus) retroviruses to chemical molecules having an inhibiting activity on a viral protease or to therapeutic treatments based on inhibitors of the viral protease, including causing cell lysis of at least one yeast by expression of the retrovirus protease.
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