A driving mechanism for a labeling machine aims to drive a transmission assembly thereof from a power source through a linking member such as a belt. The transmission assembly concurrently drives rotation of an axle assembly so that a feeding wheel coupled on an axle can draw and convey a roll of film. A belt with teeth formed on two sides serves as a transmission member of the transmission assembly to transmit rotation to two axle wheels. The transmission assembly can transmit rotation accurately, rapidly and concurrently. The structure of the transmission assembly is simplified. Wearing can be reduced. Repair and maintenance also are easier.