In a method for generation of 3D x-ray image data of a subject, a number of initial 2D x-ray images of the subject are acquired from various viewing directions. A number of noise-filtered 2D x-ray images are produced by, for each noise-filtered 2D image, combining at least two of the initial 2D x-ray images with noise filtering. 3D x-ray image data are generated from the noise-filtered 2D x-ray images.