Invention Grant
US07972870B2 Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3
失效
与HSF1和STAT3调节MUC1有关的方法和成分
- Patent Title: Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3
- Patent Title (中): 与HSF1和STAT3调节MUC1有关的方法和成分
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Application No.: US12024692Application Date: 2008-02-01
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Publication No.: US07972870B2Publication Date: 2011-07-05
- Inventor: Donald W. Kufe
- Applicant: Donald W. Kufe
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Fulbright & Jaworski
- Main IPC: G01N33/567
- IPC: G01N33/567 ; G01N33/543
Abstract:
This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or inflammatory cell growth and/or activation. The invention provides methods of inhibiting interactions between MUC1 and a heat shock factor, method of inhibiting interactions between transcription factors and the MUC1 promoter, and methods of inhibiting MUC1 expression. The invention also provides screening methods for identifying compounds that inhibit the aforementioned interactions. Pharmaceutical compositions containing the identified compounds can be useful in treating cancers and inflammatory conditions.
Public/Granted literature
- US20090092600A1 METHODS AND COMPOSITIONS RELATING TO THE REGULATION OF MUC1 BY HSF1 AND STAT3 Public/Granted day:2009-04-09
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