Invention Grant
- Patent Title: Recombinant attenuated clostridium organisms and vaccine
- Patent Title (中): 重组减毒梭菌生物体和疫苗
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Application No.: US12869813Application Date: 2010-08-27
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Publication No.: US07972604B2Publication Date: 2011-07-05
- Inventor: Mark D. Cochran , Gary R. Peterson , Stephen V. Lair , Richard M. Synenki
- Applicant: Mark D. Cochran , Gary R. Peterson , Stephen V. Lair , Richard M. Synenki
- Applicant Address: US NJ Summit
- Assignee: Intervet Inc.
- Current Assignee: Intervet Inc.
- Current Assignee Address: US NJ Summit
- Main IPC: A61K39/02
- IPC: A61K39/02
Abstract:
The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.
Public/Granted literature
- US20110008389A1 RECOMBINANT ATTENUATED CLOSTRIDIUM ORGANISMS AND VACCINE Public/Granted day:2011-01-13
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