Invention Grant
US07956196B2 1,3-dihydro-benzimidazol-2-ylidene amines as inhibitors of respiratory syncytial virus replication
有权
1,3-二氢 - 苯并咪唑-2-亚基胺作为呼吸道合胞病毒复制的抑制剂
- Patent Title: 1,3-dihydro-benzimidazol-2-ylidene amines as inhibitors of respiratory syncytial virus replication
- Patent Title (中): 1,3-二氢 - 苯并咪唑-2-亚基胺作为呼吸道合胞病毒复制的抑制剂
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Application No.: US11908538Application Date: 2006-03-17
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Publication No.: US07956196B2Publication Date: 2011-06-07
- Inventor: Jean-François Bonfanti , Jérôme Michel Claude Fortin , Ismet Dorange
- Applicant: Jean-François Bonfanti , Jérôme Michel Claude Fortin , Ismet Dorange
- Applicant Address: IE
- Assignee: Tibotec Pharmaceuticals Ltd.
- Current Assignee: Tibotec Pharmaceuticals Ltd.
- Current Assignee Address: IE
- Priority: EP05102127 20050317
- International Application: PCT/EP2006/060852 WO 20060317
- International Announcement: WO2006/097534 WO 20060921
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; A61K31/5377 ; C07D235/30 ; C07D401/12 ; C07D401/14 ; C07D413/14

Abstract:
Novel 1,3-dihydro-benzimidazol-2-ylidene amine derivatives of formula the addition salts and stereochemically isomeric forms wherein each Alk is C1-6alkanediyl; Q is hydrogen; C1-6alkyl substituted with one or two Ar2 radicals; C1-6alkyl substituted with quinolinyl, oxazolidinyl, thiazolidinyl, morpholinyl, thiomorpholinyl, or with pyrrolidinonyl; —CO—Ar2; or Q is a radical of formula wherein t is 1, 2 or 3; R4 is amino, mono-or di(C1-6alkyl)amino; R1 is Ar2, —CO—Ar2 or a monocyclic or bicyclic heterocycle which may optionally be substituted; R2 is as R1 and additionally can be hydrogen; where Q is other than hydrogen, R3 is hydrogen; and where Q is other than hydrogen, R3 is a radical: wherein R6 is hydrogen, C1-6alkyl, substituted C1-6alkyl; R7, R8, R9 are halo, cyano, C1-6alkyl, substituted C1-6alkyl, C2-6alkenyl, cyanoC2-6alkenyl, C2-6alkynyl, cyanoC2 6alkynyl, Ar1, R10a—0—, R10a—S—, —N(R5aR5b), R10a—O—C(═O)—, N(R5aR5b)—C(═O)—, R10a—C(═O)—NR5b—, R10b—C(═O)—O—; and R8 and/or R9 may also be hydrogen; which are RSV inhibitors. Compositions containing these compounds and processes for preparing these compounds and compositions.
Public/Granted literature
- US20080146564A1 1,3-Dihydro-Benzimidazol-2-Ylidene Amines as Inhibitors of Respiratory Syncytial Virus Replication Public/Granted day:2008-06-19
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