Invention Grant
- Patent Title: Indole derivative having PGD2 receptor antagonist activity
- Patent Title (中): 具有PGD2受体拮抗剂活性的吲哚衍生物
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Application No.: US11989138Application Date: 2006-07-20
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Publication No.: US07956082B2Publication Date: 2011-06-07
- Inventor: Akira Kugimiya , Michitaka Shichijo , Yoshiharu Hiramatsu , Natsuki Ishizuka
- Applicant: Akira Kugimiya , Michitaka Shichijo , Yoshiharu Hiramatsu , Natsuki Ishizuka
- Applicant Address: JP Osaka
- Assignee: Shionogi & Co., Ltd
- Current Assignee: Shionogi & Co., Ltd
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2005-212874 20050722
- International Application: PCT/JP2006/314345 WO 20060720
- International Announcement: WO2007/010964 WO 20070125
- Main IPC: A61K31/496
- IPC: A61K31/496 ; A61K31/4439 ; A61K31/404 ; A61K31/454 ; A61P25/28 ; C07D487/00 ; C07D401/02 ; C07D403/02

Abstract:
The present invention creates an indole derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.A compound of the generic formula (I) wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a 3- to 8-membered nitrogen-containing non-aromatic heterocyclic ring etc.; R1, R2, R3, R4 and R5 are independently a hydrogen atom or a halogen atom etc.; R6 is C2-C4 alkyloxy etc.; R7 is independently a halogen atom etc.; R8 is independently C1-C4 alkyl etc.; R9 is carboxy etc.; Y is a single bond etc.; M is sulfonyl etc.; L1, L2 and L3 are a single bond or alkylene optionally containing one or two heteroatoms etc.; n is 0 etc.; q is 0 etc.;a pharmaceutically acceptable salt or hydrate thereof.
Public/Granted literature
- US20090030014A1 Indole Derivative Having Pgd2 Receptor Antagonist Activity Public/Granted day:2009-01-29
Information query
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