Invention Grant
US07956075B2 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
有权
具有5个成员的杂环衍生物，其制备及其作为药物的用途
- Patent Title: Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
- Patent Title (中): 具有5个成员的杂环衍生物，其制备及其作为药物的用途
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Application No.: US12001439Application Date: 2007-12-11
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Publication No.: US07956075B2Publication Date: 2011-06-07
- Inventor: Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
- Applicant: Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
- Applicant Address: FR Boulogne-Billancourt
- Assignee: Ipsen Pharma S.A.S.
- Current Assignee: Ipsen Pharma S.A.S.
- Current Assignee Address: FR Boulogne-Billancourt
- Agency: Hunton & Williams, LLP
- Main IPC: A61K31/425
- IPC: A61K31/425 ; C07D277/28
Abstract:
The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl and Ω is —NR46R47 or —OR48, R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.
Public/Granted literature
- US20080146627A1 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments Public/Granted day:2008-06-19
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