Invention Grant
US07956062B2 Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
有权
具有一氧化氮生物活性的活性氧发生酶抑制剂及其应用
- Patent Title: Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
- Patent Title (中): 具有一氧化氮生物活性的活性氧发生酶抑制剂及其应用
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Application No.: US12554249Application Date: 2009-09-04
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Publication No.: US07956062B2Publication Date: 2011-06-07
- Inventor: Jonathan S. Stamler , Eric J. Toone , Joshua M. Hare
- Applicant: Jonathan S. Stamler , Eric J. Toone , Joshua M. Hare
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Bacon & Thomas, PLLC
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D487/04
Abstract:
A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury, atherosclerosis, sickle cell disease, diabetes, Alzheimer's disease, Parkinson's disease, ALS and asthma and to obtain proper contraction of heart, skeletal and smooth muscle.
Public/Granted literature
- US20100010019A1 Reactive Oxygen Generating Enzyme Inhibitor With Nitric Oxide Bioactivity and Uses Thereof Public/Granted day:2010-01-14
Information query
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