Invention Grant
US07956061B2 Bicyclic pyrimidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
有权
二环嘧啶作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
- Patent Title: Bicyclic pyrimidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
- Patent Title (中): 二环嘧啶作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病
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Application No.: US11793093Application Date: 2006-01-18
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Publication No.: US07956061B2Publication Date: 2011-06-07
- Inventor: Wallace T. Ashton , Charles G. Caldwell , Hong Dong , Ying-Duo Gao , Giovanna Scapin , Ann E. Weber
- Applicant: Wallace T. Ashton , Charles G. Caldwell , Hong Dong , Ying-Duo Gao , Giovanna Scapin , Ann E. Weber
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Janet E. Fair; John C. Todaro
- International Application: PCT/US2006/001660 WO 20060118
- International Announcement: WO2006/078676 WO 20060727
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61P3/10
Abstract:
The present invention is directed to novel substituted bicyclic pyrimidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Public/Granted literature
- US20090105210A1 Bicyclic Pyrimidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes Public/Granted day:2009-04-23
Information query
