Invention Grant
- Patent Title: Cytoprotective therapeutic agents for the prevention of reperfusion injury following ischemic stroke
- Patent Title (中): 用于预防缺血性卒中后再灌注损伤的细胞保护治疗剂
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Application No.: US11479776Application Date: 2006-06-30
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Publication No.: US07956037B2Publication Date: 2011-06-07
- Inventor: Darryl R. Peterson
- Applicant: Darryl R. Peterson
- Applicant Address: US IL North Chicago
- Assignee: Rosalind Franklin University of Medicine and Science
- Current Assignee: Rosalind Franklin University of Medicine and Science
- Current Assignee Address: US IL North Chicago
- Agency: Rockey, Depke & Lyons, LLC
- Agent Joseph A. Fuchs; Avani C. Macaluso
- Main IPC: A61K38/05
- IPC: A61K38/05
Abstract:
The present invention relates generally to the use of γ-glutamyl antioxidants, particularly γ-glutamyl-cysteine, as cytoprotective agents to prevent reperfusion injury (i.e., hemorrhagic transformation) of the blood-brain barrier during reperfusion following an ischemic stroke. The γ-glutamyl antioxidants can be used alone or used in combination with an agent which inhibits the reverse movement of Na/Ca exchange in the blood-brain barrier such as 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulphonate (KB-R7943).
Public/Granted literature
- US20070293436A1 Cytoprotective thereapeutic agents for the prevention of reperfusion injury following ischemic stroke Public/Granted day:2007-12-20
Information query
IPC分类:
