Invention Grant
US07947807B2 Method for obtaining G protein-coupled receptor (GPCR) diffraction-quality crystals employing a monoclonal antibody that binds to the third intracellular loop (IL3)
失效
使用结合第三细胞内环（IL3）的单克隆抗体获得G蛋白偶联受体（GPCR）衍射质量晶体的方法
- Patent Title: Method for obtaining G protein-coupled receptor (GPCR) diffraction-quality crystals employing a monoclonal antibody that binds to the third intracellular loop (IL3)
- Patent Title (中): 使用结合第三细胞内环（IL3）的单克隆抗体获得G蛋白偶联受体（GPCR）衍射质量晶体的方法
-
Application No.: US12284245Application Date: 2008-09-19
-
Publication No.: US07947807B2Publication Date: 2011-05-24
- Inventor: Brian Kobilka , Dan Rohrer , Peter Brams , Asna Masood
- Applicant: Brian Kobilka , Dan Rohrer , Peter Brams , Asna Masood
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis LLP
- Agent James S. Keddie
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C12P21/08 ; B01D9/00
Abstract:
An antibody that specifically binds a three dimensional epitope on the IC3 loop of a GPCR is provided. The antibody may be employed in a method that comprises: contacting a GPCR with a monovalent version of the antibody binding conditions to form a complex; and crystallizing the complex.
Public/Granted literature
- US20090148510A1 GPCR crystalization method using an antibody Public/Granted day:2009-06-11
Information query
