Invention Grant
US07947689B2 Substituted pyrazolo[1,5-a]pyrimidines as metabotropic glutamate receptor modulators
失效
取代的吡唑并[1,5-a]嘧啶作为代谢型谷氨酸受体调节剂
![Substituted pyrazolo[1,5-a]pyrimidines as metabotropic glutamate receptor modulators](/docs/US/2011-05-24/US07947689B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrazolo[1,5-a]pyrimidines as metabotropic glutamate receptor modulators
- Patent Title (中): 取代的吡唑并[1,5-a]嘧啶作为代谢型谷氨酸受体调节剂
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Application No.: US11890211Application Date: 2007-08-03
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Publication No.: US07947689B2Publication Date: 2011-05-24
- Inventor: Wojciech Danysz , Andrzej Dekundy , Mirko Hechenberger , Markus Henrich , Claudia Jatzke , Jens Nagel , Christopher Graham Raphael Parsons , Tanja Weil , Juris Fotins , Aleksandrs Gutcaits , Ivars Kalvinsh , Ronalds Zemribo , Valerjans Kauss
- Applicant: Wojciech Danysz , Andrzej Dekundy , Mirko Hechenberger , Markus Henrich , Claudia Jatzke , Jens Nagel , Christopher Graham Raphael Parsons , Tanja Weil , Juris Fotins , Aleksandrs Gutcaits , Ivars Kalvinsh , Ronalds Zemribo , Valerjans Kauss
- Applicant Address: DE Frankfurt am Main
- Assignee: Merz Pharma GmbH & Co. KGaA
- Current Assignee: Merz Pharma GmbH & Co. KGaA
- Current Assignee Address: DE Frankfurt am Main
- Agency: Hueschen and Sage
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61P25/28 ; A61P25/02 ; A61P35/00 ; A61P25/22
![Substituted pyrazolo[1,5-a]pyrimidines as metabotropic glutamate receptor modulators](/abs-image/US/2011/05/24/US07947689B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to pyrazolopyrimidine derivatives of formula (I) wherein Y1, Y2 and Y3 independently are e.g. CR10, NH, S or O, whereby at least one of Y1, Y2 and Y3 represents CR10; R1 represents chloro or bromo; R2, R3, R4, R5, R6 and R7 represent e.g. hydrogen or C1-C6-alkyl, and R10 represents e.g. hydrogen, halogen or phenyl; which are potent mGluR5 modulators and are e.g. useful for the treatment of various neurological disorders.
Public/Granted literature
- US20080039476A1 Pyrazolopyrimidines, a process for their preparation and their use as medicine Public/Granted day:2008-02-14
Information query
