Invention Grant
US07947683B2 3-(1,2,4-triazol-3-ylalkyl) azabicyclo (3.1.0) hexane derivatives as modulators of dopamine D3 receptors
失效
3-（1,2,4-三唑-3-基烷基）氮杂双环（3.1.0）己烷衍生物作为多巴胺D3受体的调节剂
- Patent Title: 3-(1,2,4-triazol-3-ylalkyl) azabicyclo (3.1.0) hexane derivatives as modulators of dopamine D3 receptors
- Patent Title (中): 3-（1,2,4-三唑-3-基烷基）氮杂双环（3.1.0）己烷衍生物作为多巴胺D3受体的调节剂
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Application No.: US11911027Application Date: 2006-04-12
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Publication No.: US07947683B2Publication Date: 2011-05-24
- Inventor: Giorgio Bonanomi , Anna Checchia , Elettra Fazzolari , Dieter Hamprecht , Fabrizio Micheli , Luca Tarsi , Silvia Terreni
- Applicant: Giorgio Bonanomi , Anna Checchia , Elettra Fazzolari , Dieter Hamprecht , Fabrizio Micheli , Luca Tarsi , Silvia Terreni
- Applicant Address: GB Greenford, Middlesex
- Assignee: Glaxo Group Limted
- Current Assignee: Glaxo Group Limted
- Current Assignee Address: GB Greenford, Middlesex
- Agent Bonnie L. Deppenbrock
- Priority: GB0507602.1 20050414
- International Application: PCT/EP2006/003554 WO 20060412
- International Announcement: WO2006/108701 WO 20061019
- Main IPC: C07D249/08
- IPC: C07D249/08 ; C07D403/14 ; C07D401/14 ; C07D263/30 ; C07D417/14 ; A61K31/4196 ; A61K31/501 ; A61K31/4439 ; A61K31/426 ; A61K31/4709 ; A61P25/18
Abstract:
The present invention relates to novel compounds of formula (I) or pharmaceutically acceptable salt thereof: processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, premature ejaculation or cognition impairment.
Public/Granted literature
- US20090124629A1 3-(1,2,4-TRIAZOL-3YLALKYL) AZABRICLO (3.1.0) HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS Public/Granted day:2009-05-14
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