Invention Grant
- Patent Title: Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation
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Application No.: US12872438Application Date: 2010-08-31
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Publication No.: US07939677B2Publication Date: 2011-05-10
- Inventor: Balkrishen Bhat , Prasad Dande , Thazha P. Prakash , Charles Allerson , Eric E. Swayze , Richard H. Griffey
- Applicant: Balkrishen Bhat , Prasad Dande , Thazha P. Prakash , Charles Allerson , Eric E. Swayze , Richard H. Griffey
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Jones Day
- Main IPC: C07D409/04
- IPC: C07D409/04
Abstract:
The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification.
Public/Granted literature
- US20100324277A1 OLIGOMERIC COMPOUNDS COMPRISING 4'-THIONUCLEOSIDES FOR USE IN GENE MODULATION Public/Granted day:2010-12-23
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