Invention Grant
- Patent Title: Multistep process for the physical depolymerization of heparin and products obtained therefrom
- Patent Title (中): 用于肝素物理解聚和由其获得的产物的多步法
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Application No.: US11279699Application Date: 2006-04-13
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Publication No.: US07939512B2Publication Date: 2011-05-10
- Inventor: Luigi De Ambrosi , Sergio Gonella , Donata Bensi , Giangiacomo Torri , Antonella Bisio , Elena Vismara
- Applicant: Luigi De Ambrosi , Sergio Gonella , Donata Bensi , Giangiacomo Torri , Antonella Bisio , Elena Vismara
- Applicant Address: IT Milan
- Assignee: Laboratori Derivati Organici SpA
- Current Assignee: Laboratori Derivati Organici SpA
- Current Assignee Address: IT Milan
- Agency: Baker Botts L.L.P.
- Main IPC: A61K31/727
- IPC: A61K31/727 ; C08B37/10
Abstract:
The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two γ-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.
Public/Granted literature
- US20070082869A1 MULTISTEP PROCESS FOR THE PHYSICAL DEPOLYMERIZATION OF HEPARIN AND PRODUCTS OBTAINED THEREFROM Public/Granted day:2007-04-12
Information query
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