Invention Grant
US07939490B2 TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death
有权
TWEAK作为治疗与脑水肿和细胞死亡相关的中枢神经系统疾病的治疗靶点
- Patent Title: TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death
- Patent Title (中): TWEAK作为治疗与脑水肿和细胞死亡相关的中枢神经系统疾病的治疗靶点
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Application No.: US11718786Application Date: 2005-11-08
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Publication No.: US07939490B2Publication Date: 2011-05-10
- Inventor: Jeffrey A. Winkles , Manuel S. Yepes
- Applicant: Jeffrey A. Winkles , Manuel S. Yepes
- Applicant Address: US MD Baltimore
- Assignee: University of Maryland, Baltimore
- Current Assignee: University of Maryland, Baltimore
- Current Assignee Address: US MD Baltimore
- Agency: DLA Piper LLP US
- International Application: PCT/US2005/040360 WO 20051108
- International Announcement: WO2006/052926 WO 20060518
- Main IPC: A61K39/44
- IPC: A61K39/44 ; A61K39/395 ; A61K38/16 ; A61K38/18 ; A61P25/00
Abstract:
The present invention is directed to compositions and methods for treating cerebral edema and cell death in neurological conditions characterized by disruption of the architecture of the neurovascular unit with increase in the permeability of the NVU, particularly for treating stroke. One aspect of the present invention relates to a composition comprising an agent that interferes with a TWEAK-mediated signaling pathway. Another aspect of the present invention relates to a method of using a composition which comprises an agent that inhibits Fn14 activity or Fn14 expression for the prevention and/or treatment of cerebral edema and cell death occurring in certain neurological conditions such as cerebral ischemia.
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