Invention Grant
US07939468B2 Methods of identifying compounds that target tRNA splicing endonuclease and uses of said compounds as anti-proliferative agents
有权
鉴定靶向tRNA剪接核酸内切酶的化合物的方法和所述化合物用作抗增殖剂的方法
- Patent Title: Methods of identifying compounds that target tRNA splicing endonuclease and uses of said compounds as anti-proliferative agents
- Patent Title (中): 鉴定靶向tRNA剪接核酸内切酶的化合物的方法和所述化合物用作抗增殖剂的方法
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Application No.: US12756786Application Date: 2010-04-08
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Publication No.: US07939468B2Publication Date: 2011-05-10
- Inventor: Christopher R. Trotta
- Applicant: Christopher R. Trotta
- Applicant Address: US NJ South Plainfield
- Assignee: PTC Therapeutics, Inc.
- Current Assignee: PTC Therapeutics, Inc.
- Current Assignee Address: US NJ South Plainfield
- Agency: Jones Day
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C40B30/06 ; C40B40/08 ; A61K31/00
Abstract:
The present invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for treating and/or preventing cancer.
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