Invention Grant
US07939274B2 Prostate cancer-related compositions, methods and kits based on DNA macroarray proteomics platforms
有权
前列腺癌相关组合物，基于DNA巨核阵列蛋白质组学平台的方法和试剂盒
- Patent Title: Prostate cancer-related compositions, methods and kits based on DNA macroarray proteomics platforms
- Patent Title (中): 前列腺癌相关组合物，基于DNA巨核阵列蛋白质组学平台的方法和试剂盒
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Application No.: US12782599Application Date: 2010-05-18
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Publication No.: US07939274B2Publication Date: 2011-05-10
- Inventor: Mark Stearns , Youji Hu , Min Wang
- Applicant: Mark Stearns , Youji Hu , Min Wang
- Applicant Address: US PA Philadelphia
- Assignee: Philadelphia Health and Education Corporation
- Current Assignee: Philadelphia Health and Education Corporation
- Current Assignee Address: US PA Philadelphia
- Agency: Riverside Law LLP
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/567 ; G01N33/574 ; G01N33/48 ; G01N1/00 ; G01N1/18 ; C12Q1/00
Abstract:
The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates to methods of detecting and treating prostate cancer, comprising modulating or detecting PCADM-1 expression and/or production and activity of PCADM-1 polypeptide. Further, the invention relates to novel assays for the identification of DNA-binding proteins and the double-stranded oligonucleotide sequences that specifically bind with them. Finally, the invention relates to DNAZYMs or DNA enzymes which specifically bind PCADM-1 mRNA to inhibit PCADM-1 gene expression and thereby destroy tumor cells and tumor tissue.
Public/Granted literature
- US20100221753A1 Prostate Cancer-Related Compositions, Methods and Kits Based on DNA Macroarray Proteomics Platforms Public/Granted day:2010-09-02
Information query
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