A vehicle frame structure allowing a footrest to support an even larger force. A foot operation zone and a driver's footrest are disposed between a lower cross member disposed so as to extend laterally across front ends of a pair of left and right lower main frames and an upper cross member disposed upward of, and extending in parallel with, the lower cross member. Connection frames connecting the lower cross member with the upper cross member are disposed between the foot operation zone and the driver's footrest.