An actuating device for a transmission of a vehicle, particularly a commercial vehicle, a bus, or the like, moves a trip cam of the transmission forward or backward in the longitudinal direction, and in the transverse direction in one direction or the other transversely to the longitudinal direction. It has a spindle, which includes two axially adjacent thread sections with opposing thread directions, with a spindle nut on each thread section of the spindle, with a drive motor for each spindle nut to drive it in a rotary manner, and with a coupling member that engages with the trip cam and moves it in the longitudinal and transverse directions, and which is actuatable using the spindle.