A device and method for sorting microparticles including a nozzle for a separating stream, with a vibration generator for the dispersion of the separation flow into a droplet flow with a deflector device for separation of the droplet flow into a through flow and at least one side flow depending on signals from an analytical device configured to analyze the microparticles (s) contained in the droplets and to control the deflector device. Also provided is a protective chamber in which at least the nozzle, the oscillation generator and the deflector device are arranged. The analytical device is outside the safety cabinet wherein the protective chamber is part of the safety cabinet with a clean chamber and a monitoring device through which the signals of the microparticles arising from the separating stream are supplied to the detectors of the analytical device, arranged outside the safety cabinet.