A process for producing filler-containing polytetrafluoroethylene granules by an underwater agitation granulation method, whereby filler-containing polytetrafluoroethylene granules excellent in flowability can be obtained with little detachment of the filler and it is possible to prevent discharge of a polytetrafluoroethylene emulsion into waste liquid, the process characterized in that in a stage of granulating a mixture of polytetrafluoroethylene powder and a filler by agitation in water in the presence of a liquid organic substance hardly soluble in water, a polytetrafluoroethylene emulsion and a coagulant are added to coagulate the polytetrafluoroethylene emulsion as a surface layer of the filler-containing polytetrafluoroethylene granules.