Invention Grant
- Patent Title: Oligonucleotides which inhibit expression of the OB-RGRP protein
- Patent Title (中): 抑制OB-RGRP蛋白表达的寡核苷酸
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Application No.: US10774721Application Date: 2004-02-09
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Publication No.: US07884084B2Publication Date: 2011-02-08
- Inventor: Ralf Jockers , Cyril Couturier , Eugen Uhlmann
- Applicant: Ralf Jockers , Cyril Couturier , Eugen Uhlmann
- Applicant Address: FR Antony FR Paris FR Paris
- Assignee: Aventis Pharma S.A.,Institut National de la Sante Et de la Recherche Medicale,Centre National de la Rechercher Scientifique
- Current Assignee: Aventis Pharma S.A.,Institut National de la Sante Et de la Recherche Medicale,Centre National de la Rechercher Scientifique
- Current Assignee Address: FR Antony FR Paris FR Paris
- Priority: FR0301543 20030210
- Main IPC: C12N15/11
- IPC: C12N15/11
Abstract:
The present application relates to antisense oligonucleotides which inhibit expression of the OB-RGRP protein and to uses thereof for preventing and/or treating leptin-related pathological conditions.It also relates to a method for detecting compounds which modify the interaction between proteins of the OB-RGRP family and the leptin receptor. This detection may be carried out by measuring the energy transfer between fusion proteins composed of these proteins and of energy-donor and -acceptor proteins.
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