Invention Grant
US07883696B2 Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response
有权
通过共表达真核型I型干扰素反应抑制剂从基于细菌的递送系统增加转基因表达的方法
- Patent Title: Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response
- Patent Title (中): 通过共表达真核型I型干扰素反应抑制剂从基于细菌的递送系统增加转基因表达的方法
-
Application No.: US12558137Application Date: 2009-09-11
-
Publication No.: US07883696B2Publication Date: 2011-02-08
- Inventor: Jerald C. Sadoff , Mohamad F. Jamiluddin , Ravi P. Anantha , John F. Fulkerson, Jr.
- Applicant: Jerald C. Sadoff , Mohamad F. Jamiluddin , Ravi P. Anantha , John F. Fulkerson, Jr.
- Applicant Address: US MD Rockville
- Assignee: Aeras Global TB Vaccine Foundation
- Current Assignee: Aeras Global TB Vaccine Foundation
- Current Assignee Address: US MD Rockville
- Agency: Whitham Curtis Christofferson & Cook, PC
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07K14/00 ; C07H21/04
Abstract:
Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I interferon response to eukaryotic cells. Suppression of the eukaryotic Type I interferon response allows improved expression of the encoded transgene.
Public/Granted literature
Information query
