A golf glove has a number of regions formed of a leather-like material, connected with a more flexible region of spandex-like material. A thumb region has a base portion at least substantially surrounded by the flexible region. The thumb region further includes an auxiliary support structure on a portion of the thumb region providing additional support to the thumb of a user and anti-twist functionality reducing or eliminating movement of the glove relative to the thumb of a user. In addition, a grip region can extend from a wrist end of the glove substantially to finger tips of a little finger portion, a ring finger portion, and a middle finger portion of the glove.