Invention Grant
- Patent Title: Process for the purification of ropinirole hydrochloride
- Patent Title (中): 罗非尼罗盐酸盐的纯化方法
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Application No.: US12294994Application Date: 2007-03-21
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Publication No.: US07863462B2Publication Date: 2011-01-04
- Inventor: Pandurang Balwant Deshpande , Parven Kumar Luthra , Hitarth Harshendu Acharya
- Applicant: Pandurang Balwant Deshpande , Parven Kumar Luthra , Hitarth Harshendu Acharya
- Applicant Address: IN Vadodara
- Assignee: Alembic Limited
- Current Assignee: Alembic Limited
- Current Assignee Address: IN Vadodara
- Agency: Volpe and Koenig, P.C.
- Priority: IN475/MUM/2006 20060329
- International Application: PCT/IN2007/000117 WO 20070321
- International Announcement: WO2007/110880 WO 20071004
- Main IPC: C07D209/34
- IPC: C07D209/34
Abstract:
The present invention provides an improved process for the purification of ropinirole hydrochloride. The process includes (i) treating ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent; (ii) triturating the ropinirole hydrochloride obtained in step (i) with ethanol; (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.
Public/Granted literature
- US20100179332A1 PROCESS FOR THE PURIFICATION OF ROPINIROLE HYDROCHLORIDE Public/Granted day:2010-07-15
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