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US07863460B2 Process for producing 1-substituted-3-fluoroalkylpyrazole-4-carboxylate 有权
1-取代-3-氟代烷基吡唑-4-羧酸酯的制备方法

Process for producing 1-substituted-3-fluoroalkylpyrazole-4-carboxylate
Abstract:
In a process for producing 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylate (3) by a reaction of 2-alkoxymethylenefluoroacylacetate (1) and hydrazine (2), the reaction is conducted in the presence of a base and water, to produce 1-substituted-3-fluoroalkylpyrazole-4-carboxylate (3) with high selectivity and yield. This novel process enables to produce 1-substituted-3-fluoroalkylpyrazole-4-carboxylate (3), which is useful as an intermediate for pharmaceuticals and agrochemicals, with high selectivity and yield by simple and safe operations.
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