Invention Grant
- Patent Title: Fluorogenic enzyme substrates and methods of preparation
- Patent Title (中): 荧光酶底物及其制备方法
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Application No.: US10540057Application Date: 2003-12-26
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Publication No.: US07863428B2Publication Date: 2011-01-04
- Inventor: Inge Dierynck , Jan Ludwig Goeman , Koenraad Lodewijk August Van Acker , Johan Theo André Van Der Eycken
- Applicant: Inge Dierynck , Jan Ludwig Goeman , Koenraad Lodewijk August Van Acker , Johan Theo André Van Der Eycken
- Applicant Address: BE
- Assignee: Tibotec BVBA
- Current Assignee: Tibotec BVBA
- Current Assignee Address: BE
- Priority: EP02102898 20021227
- International Application: PCT/EP03/51105 WO 20031226
- International Announcement: WO2004/058787 WO 20040715
- Main IPC: C07H15/00
- IPC: C07H15/00 ; C07H17/00 ; C07H17/02 ; C07H15/24
Abstract:
This invention relates to hydrolase fluorogenic substrates with improved cell permeability, methods for the preparation thereof, and methods of measuring activities of hydrolases, particularly in cell-based assays. The substrates easily diffuse into the cells, where they are enzymatically processed to yield photostable fluorescent products, and are particularly fitted for visualising enzyme-derived activities in cell-based assays.
Public/Granted literature
- US20070037234A1 Fluorogenic enzyme substrates and methods of preparation Public/Granted day:2007-02-15
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