Invention Grant
US07863242B2 Compositions for down-regulation of CCR5 expression and methods of use thereof
失效
用于下调CCR5表达的组合物及其使用方法
- Patent Title: Compositions for down-regulation of CCR5 expression and methods of use thereof
- Patent Title (中): 用于下调CCR5表达的组合物及其使用方法
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Application No.: US11281195Application Date: 2005-11-16
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Publication No.: US07863242B2Publication Date: 2011-01-04
- Inventor: Robert R. Redfield , Anthony Amoroso , Charles E. Davis , Alonso Heredia
- Applicant: Robert R. Redfield , Anthony Amoroso , Charles E. Davis , Alonso Heredia
- Applicant Address: US MD Baltimore
- Assignee: University of Maryland, Baltimore
- Current Assignee: University of Maryland, Baltimore
- Current Assignee Address: US MD Baltimore
- Agency: Moore & Van Allen, PLLC
- Agent Marianne Fuierer
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K31/445 ; A61K31/33
Abstract:
The present invention relates to the downregulation of surface receptor CCR5 expression through manipulation of the cell cycle in activated lymphocytes by administering a composition that arrests the G1 phase of the cell cycle, thereby reducing receptor sites for entry of HIV into T cells, and thus, the effects of HIV. Further, compositions are disclosed that include at least one G1 phase arresting agent and at least one antiviral agent, wherein the combination of agents synergistically enhances the activity of the antiviral agent.
Public/Granted literature
- US20060154857A1 Compositions for down-regulation of CCR5 expression and methods of use thereof Public/Granted day:2006-07-13
Information query
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