A method for optimizing sound and vibration comfort in a mobile passenger compartment, the method applied by a design team to carry out overall design of the passenger compartment and/or by at least one equipment supplier to carry out design of a portion of the passenger compartment. The method establishes target values to be achieved for well-identified comfort indices, defines requirements and input data relating to plural equipment suppliers to obtain a totality of information relating to the passenger compartment, estimates values of the comfort indices and compares them with the target values, and then modifies individually or in combination the input data to correlate them with the target values.