A patient treatment arrangement is provided which includes a fixed beam irradiation source; and a patient positioning apparatus, the patient positioning apparatus comprising: a support member; a patient securing mechanism arranged to secure a patient to the patient support member; and a patient positioner in communication with the patient support member and operative to achieve positioning of the support member equivalent to rotation of the patient support member about a plurality of axes and translation of the patient support member along a plurality of axes, the patient positioner thereby providing substantially unrestricted variable angular access for irradiation of a target tissue of a patient secured to the patient securing mechanism from the fixed beam irradiation source.