Invention Grant
- Patent Title: Asymmetric reduction method
- Patent Title (中): 不对称还原法
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Application No.: US12087092Application Date: 2006-12-26
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Publication No.: US07847107B2Publication Date: 2010-12-07
- Inventor: Yoshinori Matsumoto , Yuki Takeuchi , Hiroyuki Yamamoto
- Applicant: Yoshinori Matsumoto , Yuki Takeuchi , Hiroyuki Yamamoto
- Applicant Address: JP Nagano
- Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Nagano
- Agency: Edwards Angell Palmer & Dodge LLP
- Agent Peter F. Corless; Christine C. O'Day
- Priority: JP2005-374989 20051227
- International Application: PCT/JP2006/325875 WO 20061226
- International Announcement: WO2007/077818 WO 20070712
- Main IPC: C07D209/44
- IPC: C07D209/44

Abstract:
The present invention is to provide a novel method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid which is useful as a therapeutic agent for diabetes. The present invention relates to a method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid, which is characterized in that 2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid is subjected to a catalytic reduction reaction in the presence of an asymmetric catalyst prepared from a pyrrolidinebisphosphine compound (I) represented by the following general formula (I): wherein, R1 represents a linear or branched alkyl group having 1-10 carbon atoms, cycloalkyl group, aralkyl group or aryl group which may respectively have a substituent; and R2 and R3 independently represent an optionally substituted aryl group. The * mark in the pyrrolidine ring shows that the carbon atom at that position has the S configuration, and a rhodium compound.
Public/Granted literature
- US20090043110A1 Asymmetric Reduction Method Public/Granted day:2009-02-12
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