Invention Grant
US07847100B2 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
有权
可用作治疗阿尔茨海默病的β-分泌酶抑制剂的1,3,5-取代苯基衍生物化合物
- Patent Title: 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
- Patent Title (中): 可用作治疗阿尔茨海默病的β-分泌酶抑制剂的1,3,5-取代苯基衍生物化合物
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Application No.: US11578559Application Date: 2005-04-15
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Publication No.: US07847100B2Publication Date: 2010-12-07
- Inventor: James C. Barrow , Georgia B. McGaughey , Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , Shaun R. Stauffer , Craig A. Coburn
- Applicant: James C. Barrow , Georgia B. McGaughey , Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , Shaun R. Stauffer , Craig A. Coburn
- Applicant Address: US NJ Rahway
- Assignee: Merck, Sharp & Dohme, Inc.
- Current Assignee: Merck, Sharp & Dohme, Inc.
- Current Assignee Address: US NJ Rahway
- Agent Keith D. MacMillan; John C. Todaro
- International Application: PCT/US2005/012973 WO 20050415
- International Announcement: WO2005/103020 WO 20051103
- Main IPC: A61K31/4245
- IPC: A61K31/4245 ; C07D271/10 ; C07D271/06
Abstract:
The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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